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The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes α\alpha

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The mouse thymus normally contains about 1–2 x 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCR α\alpha locus are compared with those from TCR β\beta -deficient mice, a striking difference between the two different knockout lines is observed, as shown in Figure in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots.
The mouse thymus normally contains about 1–2 x 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCR \alpha locus are compared with those from TCR \beta -deficient mice, a striking difference between the two different knockout lines is observed, as shown in Figure in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots. -Which region of the thymus organ would show a dearth of developing thymocytes in the TCR \alpha <sup>-/-</sup> thymus? Which region in the TCR \beta <sup>-/-</sup> thymus?
-Which region of the thymus organ would show a dearth of developing thymocytes in the TCR α\alpha -/- thymus? Which region in the TCR β\beta -/- thymus?

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