The NBT (Nitro Blue Tetrazolium) Test Is Used to Diagnose

question 33

Essay

The NBT (Nitro Blue Tetrazolium) test is used to diagnose the genetic disorder Chronic Granulomatous Disease (CGD). To perform this test, peripheral blood cells from the patient are stimulated with bacterial extracts, and then incubated with the NBT compound. Normal neutrophils turn blue in this test due to cleavage of the compound, while patient neutrophils remain uncolored, as shown in Figure.
Name a neutrophil receptor that is likely to be stimulated by the bacterial extract in this assay, and describe how this receptor regulates the activity of the enzyme that cleaves NBT.

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Definitions:

Withdrawn

A behavioral state characterized by a lack of social interaction and communication, often as a response to stress, anxiety, or depression.

Lonely

A complex and usually unpleasant emotional response to isolation or lack of companionship, which may include feelings of sadness, emptiness, or abandonment.

Mental Stimulation

Activities that engage, challenge, and enhance cognitive functions such as thinking, understanding, and memory.

Physical Exercise

A regimen or activity intended to improve and maintain physical fitness and health.