In Patients with 'CD40 Ligand Deficiency', T Cell-Dependent B Cell $\kappa$

question 25

Multiple Choice

In patients with 'CD40 ligand deficiency', T cell-dependent B cell activation is impaired, leading to poor antibody responses to protein antigens. The signaling pathway missing in these patients' B cells is important for:

• A) Inducing integrin activation to promote adhesion
• B) Inducing NF\(\kappa\)B activation by the noncanonical pathway
• C) Inducing WASp activation and actin polymerization
• D) Inducing Ca²⁺ influx leading to NFAT activation
• E) Inducing Ras activation and Erk Map-kinase signaling

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