Several Types of Pathogens Encode Proteins That Function as Superantigens

question 22

Multiple Choice

Several types of pathogens encode proteins that function as superantigens, which activate massive numbers of T cells in an individual. One example is the staphylococcal enterotoxins that cause food poisoning. These superantigens are the exception to the general rule that T cells only recognize specific peptide:MHC complexes, because they:

• A) Induce activation of any T cell whose T-cell receptor uses a particular Vβ region bound by that superantigen
• B) Simultaneously stimulate all of the T-cell receptors on a given T cell
• C) Cover up the peptide-binding site, preventing MHC molecules from binding peptides
• D) Activate a large number of T cells that are specifically recognizing peptides derived from the superantigen protein
• E) Induce anti-microbial cytokine production that aids the immune system in clearing the pathogen

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