The Extensive Polymorphism of MHC Genes in the Population Is

question 23

Multiple Choice

The extensive polymorphism of MHC genes in the population is thought to represent an evolutionary response to outflank the evasive strategies of pathogens. This polymorphism makes it difficult for pathogens to eliminate all potential MHC binding epitopes from their proteins. Based on this reasoning, it would seem advantageous for each individual to encode more than three different MHC class I and three different MHC class II genes per chromosome copy. If some individuals in the population had MHC loci that encoded 10 different MHC class I and 10 different MHC class II genes, the T cell repertoire in those individuals would likely be:

• A) Much more diverse than in the rest of the individuals of that population
• B) Much better at recognizing rare pathogens not encountered by most individuals in that population
• C) Much less diverse than the rest of the individuals in that population
• D) Much more alloreactive than the T cells found in the other individuals of that population
• E) Very reactive to bacterial and viral superantigens

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Definitions:

Osteoarthritis

A type of arthritis that occurs when flexible tissue at the ends of bones wears down, leading to pain, swelling, and reduced motion in joints.

Leukemia

A cancer of the blood and bone marrow, defined by the overabundance of irregular white blood cells.

Singular

Referring to a single unit or individual element, as opposed to multiple items or a group.

Plural

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