Some CD1 Molecules Bind to Glycosphingolipids, and Are Recognized by a Subset

question 13

Multiple Choice

Some CD1 molecules bind to glycosphingolipids, and are recognized by a subset of T cells known as invariant NKT (iNKT) cells. The ability of these T cells to recognize different glycolipid constituents from microorganisms when they are bound to CD1d places these cells in the 'innate immune' category. While iNKT cells do express a fully rearranged $\alpha$ : $\beta$ T-cell receptor, one key feature of the T-cell receptors expressed on iNKT cells also places them in the 'innate immune' category. This feature is:

• A) iNKT cells have a highly restricted T-cell receptor repertoire, with the majority of cells utilizing the same V\(\alpha\) and J\(\alpha\) rearrangement.
• B) iNKT cells express receptors that are also expressed on NK cells.
• C) iNKT cells express T-cell receptors that induce inhibitory, rather than activating signals.
• D) iNKT cells do not generally express CD4 or CD8.
• E) The T-cell receptors expressed on iNKT cells recognize both MHC class I and MHC class II molecules.

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Definitions:

Dietary Intake

The amount of food and drink consumed by an individual or group.

Thoracic Duct

Largest lymph vessel in the body, beginning at the cisterna chyli and emptying into the left subclavian vein; drains the left side of the head and neck, the left-upper thorax, the left-upper limb, and the inferior half of the body.

Circulatory System

The body's system responsible for the transport of blood, nutrients, oxygen, carbon dioxide, and hormones throughout the body.

Lipids

A group of naturally occurring molecules that include fats, waxes, sterols, and fat-soluble vitamins, among others, used by the body for energy and making up cell membranes.