The Genes Encoding MHC Proteins Are Closely Linked with Genes

question 18

True/False

The genes encoding MHC proteins are closely linked with genes encoding proteins involved in antigen processing and presentation. This genetic linkage facilitates the coordinate regulation of these genes by interferons.

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Definitions:

Dosage Compensation

Genetic mechanism by which the expression of X-linked genes is made equivalent in XX females and XY males; in mammals this is accomplished by rendering all but one X chromosome inactive.

X Chromosome Inactivation

A process by which one of the copies of the X chromosome present in female mammals is inactivated, ensuring that males and females have the same dose of the X chromosome genes.

X Chromosome Inactivation Center (XIC)

A critical region on the X chromosome that controls the process of X chromosome inactivation during female development.

Codominance

A genetic scenario where two alleles of a gene pair in a heterozygote are fully expressed, resulting in offspring with a phenotype that is neither dominant nor recessive.