Chemokines Such as CXCL8 Have a Key Role in the Rapid

question 36

Multiple Choice

Chemokines such as CXCL8 have a key role in the rapid recruitment of neutrophils to the site in the tissue containing the focus of an infection. In this response, CXCL8 has two different functions. In addition to inducing integrin activation on the neutrophil, CXCL8 also functions to:

• A) Induce directional migration of the neutrophil in the tissue
• B) Induce increased expression of P-selectin and E-selectin on the endothelium
• C) Induce increased expression of integrins on the neutrophil surface
• D) Induce blood vessel dilation and fluid leakage into the infected tissue
• E) Induce increased phagocytic activity by the neutrophil

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