The Antibody Surface Involved in Antigen Binding Varies Depending on the Size

question 21

Multiple Choice

The antibody surface involved in antigen binding varies depending on the size and nature of the antigen. This surface can be concave or flat, and sometimes, can have extended protrusions. This is accomplished by:

• A) Flexibility in the hinge regions of the antibody allowing rotation of the antigen-binding sites
• B) Some antibodies using V region framework sequences instead of the CDRs to bind antigen
• C) The ability of different CDR sequences to form many structurally distinct shapes and surfaces
• D) The ability of the same heavy chain to pair with different light chains
• E) The differential usage of κ versus λ light chains, as κ chains form concave binding sites whereas λ chains make flatter surfaces

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Definitions:

Cubism

An early-20th-century art movement that rejected naturalistic depictions, preferring compositions of shapes and forms abstracted from the conventionally perceived world. See also Analytic Cubism and Synthetic Cubism.

Illusionistic Perspective

An artistic technique used to create the illusion of depth and three-dimensionality on a flat surface, often seen in Renaissance paintings.

Concrete Irrationality

A notion in philosophy that suggests the presence of irrational aspects in concrete reality, challenging the predominance of rational thought in understanding existence.

René Magritte

A Belgian surrealist artist known for his thought-provoking images that challenge observers' preconditioned perceptions of reality.