Some Viruses Encode a Protease That Cleaves the Translation Initiation

question 17

Multiple Choice

Some viruses encode a protease that cleaves the translation initiation factor eIF4G, rendering it unable to bind to eIF4E. What is the consequence of this cleavage?

• A) It shuts down most of the cellular translation machinery, which causes the release of virus particles.
• B) It favors viral protein synthesis because IRES-dependent translation initiation is inhibited.
• C) It shuts down most host-cell protein synthesis and diverts the translation machinery to IRES-dependent initiation, thus favoring viral protein synthesis.
• D) It favors viral protein synthesis by shutting down translation from uORFs.
• E) It shuts down IRES-dependent translation, forcing the virus into latency.

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