AIRE Is a Transcriptional Regulator That Promotes the Expression of Some

question 3

Multiple Choice

AIRE is a transcriptional regulator that promotes the expression of some 'tissue-specific' proteins in thymic stromal cells. This provides a means to induce central tolerance of developing T cells to these antigens. Patients with inactivating mutations in AIRE (a disease known as APECED) develop a range of symptoms, several of which involve autoimmune attack of exocrine glands. However, analysis of many patients with APECED reveals that some organs in the body are never attacked by autoimmune T cells in individuals with this syndrome, whereas other organs are commonly found to be destroyed in these patients. This targeted autoimmune response against a subset of tissues in APECED patients indicates:

• A) Some tissues in the body cannot be targeted by autoimmune mechanisms.
• B) AIRE likely regulates genes expressed in this subset of tissues, but not genes in other tissues.
• C) Central tolerance is more efficient in deleting T cells reactive to some tissues in the body than others.
• D) Central tolerance is only important for deleting auto-reactive T cells recognizing self-antigens expressed in exocrine glands.
• E) Exocrine glands express much higher levels of self-antigens than other tissues do.

Appreciate the continuum of offerings between tangible products and intangible services.

Recognize the cost structures associated with service delivery, including inventory carrying costs.

Understand how services can be classified by various criteria including the level of tangible vs. intangible attributes, and the sector (public, private, nonprofit).

Understand the different debt instruments used by public corporations to finance their activities.

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Definitions:

Liquid

Describes an asset's ability to be quickly converted into cash without significant loss in value.

Maturity Date

The maturity date is the specified date on a financial instrument at which the principal (or final payment) is due to be paid to the holder.

Retained Earnings

The portion of a company's net income that is not distributed to shareholders as dividends but is retained by the company to reinvest in its core business or to pay debt.