T_reg Cells That Express FoxP3 Are Generally Thought to Have $\beta$

question 4

Multiple Choice

T_reg cells that express FoxP3 are generally thought to have T-cell receptors that recognize self-peptides bound to MHC class II molecules. In the skin, keratin and filaggrin are among the self-antigens expressed. FoxP3+ T_reg cells found in skin and skin-draining lymph nodes might be specific for the self-antigen, filaggrin. These FoxP3+ filaggrin-specific T_reg cells:

• A) Would inhibit the activation of naive filaggrin-specific and keratin-specific CD4 T cells
• B) Would only inhibit the activation of naive filaggrin-specific CD4 T cells
• C) Would inhibit the activation of all naive T cells in skin-draining lymph nodes following an infection
• D) Would not inhibit naive T cells specific for antigens expressed by commensal microbes but not by host cells
• E) Are the only subset of autoreactive cells expressing TGF-\(\beta\) receptors

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