10) a Mouse Model for Autoimmune Hemolytic Anemia Can Be

question 28

Multiple Choice

10) A mouse model for autoimmune hemolytic anemia can be transferred to naive mice by a single injection of anti-red blood cell IgG antibodies. However, the disease is prevented if recipient mice lack IgG-binding Fc receptors. These data indicate:

• A) An essential role for NK cells, neutrophils and other granulocytes, and macrophages in red blood cell destruction
• B) An essential role for the transport of IgG out of the blood into the tissues for red blood cell destruction
• C) A critical role for innate immune cells in the development of autoreactive antibody-secreting B cells
• D) That phagocytosis of antibody-coated red blood cells is only mechanism leading to red blood cell destruction
• E) Autoantibodies can traffic to the bone marrow and destroy erythroid progenitor cells

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Definitions:

Discounting

The process of determining the present value of a payment or series of payments that will be received in the future.

Present Value Interest Factor

A factor used to calculate the present value of a sum that is to be received in the future, accounting for the time value of money.

Non-Interest Bearing Note

A debt instrument that does not pay interest but is issued at a discount to its redemption value.

Present Value

The current value of a future sum of money or stream of cash flows given a specified rate of return, used to assess the worth of an investment.