NRF2 Is a Transcription Factor That Is Required to Induce

question 19

Multiple Choice

NRF2 is a transcription factor that is required to induce anti-oxidant genes, such as glutathione-S-transferase genes, in response to reactive oxygen and reactive nitrogen species released by inflammatory cells in the airways following phagocytosis of inhaled particles. Mice deficient in Nrf2 were tested for their allergic airway response to inhaled allergens in comparison to wild-type controls. Compared to wild type mice, the Nrf2^-/- mice would be expected to show:

• A) Reduced recruitment of eosinophils to the airway mucosa
• B) Enhanced production of IL-17 and IL-22 required to repair damaged epithelium
• C) Increased levels of IL-4 and IL-13 in the airway
• D) Increased numbers of CD4 T_reg cells in the airway epithelium
• E) Reduced levels of allergen-specific IgE

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