One of the First Studies Using Peptide:MHC Class I Tetramers

question 11

Essay

One of the first studies using peptide:MHC class I tetramers to measure the frequencies of virus-specific CD8 T cells in an acute virus infection in mice demonstrated the remarkable finding that more than 50% of all the CD8 T cells in the mouse were virus-specific at the peak of the response (day 8 post-infection). This study used the virus lymphocytic choriomeningitis virus (LCMV). One peptide:MHC tetramer used in this study, H-2-D^b loaded with the LCMV nucleoprotein peptide NP_396-404, bound to ~20% of the CD8 T cells in the spleen at day 8 post-infection. Why did this tetramer only stain ~20% of the CD8 T cells if more than half of the CD8 cells in the spleen were virus-specific?

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Definitions:

Bonds Purchased

This refers to the buying of debt securities issued by corporations or governments as a means of investment.

Accrued Interest

Interest that has been incurred but not yet paid or received, often associated with bonds and loans.

Short-term Investments

Financial instruments or securities that are expected to be sold or converted into cash typically within a year or less.

Long-term Investments

Investments in other companies, real estate, or securities that a company intends to hold for more than one fiscal year.