The Bcl-2 Protein Was First Identified Based on Its Overexpression

question 1

Multiple Choice

The Bcl-2 protein was first identified based on its overexpression in a subset of B cell lymphomas, where it was shown to promote the resistance of the tumor cells to apoptosis. Subcellular localization experiments would show that Bcl-2 is present:

• A) In the nucleus, where it blocks DNA fragmentation
• B) In the cytotoxic granules where it inactivates granzymes
• C) In the mitochondria where it blocks cytochrome c release
• D) In the cytosol where it blocks caspase activation
• E) In the plasma membrane where it blocks death receptor signaling

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