Consider a Genetic Network Consisting of Gene a Whose Product

question 29

Multiple Choice

Consider a genetic network consisting of gene A whose product activates the transcription of gene R. Imagine that the concentration of protein A is suddenly changed by a significant amount. The following graphs show how the concentration of protein R would then change over time to reach steady state again. The two curves (1 and 2) in each graph correspond to systems that have different transcription rates for A. For one of the two graphs (A or B) a negative feedback loop is present, in which protein R represses the transcription of gene A. Which conclusion is correct according to these results?

• A) The negative feedback loop makes the system slower in reaching the steady state.
• B) With negative feedback, the steady-state concentration is less sensitive to fluctuations in kinetic rate constants.
• C) Higher transcription rates for gene A result in lower steady-state levels of protein R both with and without negative feedback.
• D) All of the above.

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Definitions:

Size of Territory

The concept in environmental psychology referring to the physical space controlled by an individual or group, impacting behavior and social relations.

Territorialize

The action of establishing control or ownership over a specific physical area or concept, often to assert dominance or exclusivity.

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A framework for understanding how individuals infer the causes of other people’s behavior, attributing it to either internal dispositions or external situations.

Overload Theory

A theory that suggests individuals experience stress or decreased performance when demands exceed their capacity to cope.